WELCOME TO ADCURE BIO

AdCure Bio is a pre-clinical stage cancer viro-immuno-therapy company, developing potent and safe immuno-stimulatory oncolytic viruses for therapy of solid tumors.


AdCure Bio is committed to bring patients new therapies for late-stage and disseminated metastatic cancers, refractory to immunotherapy, chemotherapy and other existing treatment modalities.

THE DIFFERENCE IN ADCURE BIO TECHNOLOGY

Our proprietary platform adenovirus configuration is engineered to safely reach and destroy cancer cells and stimulate anti-tumor immunity within non-resectable and metastatic tumors after intravenous virus administration.

Unmet need for novel Therapeutics to cure cancer

Cancer figures among the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases and 9.6 million cancer related deaths in 2018.  

The total annual economic cost of cancer in 2010 was estimated at approximately US$ 1.16 trillion.  Unfortunately, the number of new cancer cases is expected to rise by about 70% over the next 2 decades*.


Oncolytic virotherapy is a new modality for therapy of hematologic and solid cancers. As of 2018, oncolytic viruses are being evaluated in 112 clinical trials as novel anti-cancer therapeutics**. 



* WHO Cancer Statistics   http://www.who.int/mediacentre/factsheets/fs297/en/

** ClinicalTrials.gov

AdCure clinical program

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AdCure Bio's clinical development program is focused on developing new viruses that can efficiently reach disseminated cancer cells via intravascular virus delivery.


Currently, our main focus is on lung cancer, the deadliest cancer type in the US, Europe, and Asia. The American Cancer Society estimates that in the US in 2019,  there will be  205,335  new cases and  128,403  deaths due to the non-small cell lung cancer, the most prevalent lung cancer type. 

AdCure Bio's lead product: AVID-317

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The key technology platform of AdCure Bio is based on oncolytic adenovirus, a common cold virus, engineered to selectively infect and kill tumor cells and stimulate the patient's immune system to eliminate cancer cells from the body.


AdCure Bio’s one-of-a-kind Artificial Vectors for Intravascular Delivery - AVID platform - is ideal for simple intravascular administration because of its safety and unique property of escaping liver sequestration. These features make it suitable for the treatment of cancer patients with disseminated metastatic disease and non-resectable tumors, for whom no effective therapy is currently available.

NEWS and Presentations

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International Oncolytic Virus Conference, October 9-12th, 2019. Rochester, MN

Structure-guided engineering of oncolytic adenovirus for systemic cancer therapy. (Plenary Session talk)

Press Release

 On August 13, 2019, The United States Patent and Trademark Office granted AdCure utility United States Patent No. 10,376,549 titled "Detargeted adenovirus variants and related methods".   


The US Patent 10,376,549 (international application PCT/US16/13765) is the principal IP position describing generation of adenovirus variants suitable for intravenous administration for safe and effective treatment of disseminated cancers. 


All AdCure Bio drug candidates are built on the platform adenovirus configuration disclosed in the US patent 10,376,549. This platform virus configuration has been used for constructing novel oncolytic adenoviruses, which demonstrated greatly improved safety and statistically-significant anti-tumor activity in mouse models of disseminated lung cancer upon intravenous virus administration.

American Society of Gene and Cell Therapy conference, April 29, 2019. Washington DC.

Pre-clinical assessment of efficacy and safety of novel oncolytic adenovirus for therapy of disseminated lung cancer. (Poster presentation)

American Association for Cancer Research conference, April 3, 2019. Atlanta, GA

Pre-clinical assessment of efficacy and safety of novel oncolytic adenovirus for therapy of disseminated lung cancer. (Poster presentation)

Biotech Showcase-2019 / 37th JP Morgan Healthcare Conference, January 9, 2019. San Francisco, CA

Novel oncolytic AVID platform for systemic therapy of solid cancers. (Oral presentation)

American Society of Clinical Oncology conference, June 4, 2018. Chicago, IL

Development of the triple-mutant oncolytic adenovirus for treatment of metastatic cancer by means of intravascular virus administration.

Press Release

On May 29, 2018, The United States Patent and Trademark Office granted AdCure utility United States Patent No. 9982276, titled "Penton-mutated, integrin-retargeted adenovirus vectors with reduced toxicity and their use".  

AdCure BIo's pipeline

AdCure Bio's development program has been supported by over $12M of public and private funds

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 Using its versatile AVID-317 platform allowing for a safe intravenous virus delivery, AdCure Bio continues to innovate and develop novel oncolytic adenovirus therapeutics to further increase virus potency resistance to pre-existing immunity, and stimulation of patient's own immune system to attack and eliminate cancer cells.  

Intellectual property

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AdCure Bio owns unrestricted rights to its core oncolytic virus technology

U.S. Patent 9,982,276

Title: "Penton-mutated, integrin-retargeted adenovirus vectors with reduced toxicity and their use".


Issue date: May 29, 2018. Priority date: March, 12, 2015


This patent covers configuration of oncolytic adenoviruses targeted to liver cancers as well as virus variants for safe  therapeutic gene delivery to normal liver cells after intravenous virus administration.  

U.S. Patent 10,376,549

Title: "Detargeted Adenovirus Variants and Related Methods".


Priority date: January, 20th, 2015


This international patent application  PCT/US2016/013765 entered into the national stage processing in the following states/regions:


European Union - Application No. 16740545.5


Japan - Application No. 2017-556782


This U.S patent and  international patent applications cover platform adenovirus configuration suitable for intravenous administration. This platform configuration is the foundation for all currently engineered oncolytic viruses.

U.S. Continuation Patent Application Serial No. 16/460,160

U.S. Continuation Patent Application Serial No. 16/460,160 entitled: “Detargeted Adenovirus Variants and Related Methods” was filed on November 25, 2019. This continuation patent application is based on our granted US patent 10,376,549 and it expands and defines the methods and therapeutic uses of oncolytic adenovirus variants, protected under our granted parental U.S patent. 

New inventions

Invention: Synthetic adenovirus variants and their use. Invention disclosure assigned to AdCure 07/2018. PCT application in works.


This invention covers a new set of synthetic adenovirus vectors for intravascular delivery that are resistant to pre-existing immunity and amenable to a high-efficacy, industrial-scale production.



Invention: Therapeutic oncolytic adenoviruses expressing transgenes and their use. Invention disclosure assigned to AdCure 07/2018. PCT application in works.


This invention covers a new set of synthetic adenovirus vectors for intravascular delivery that attract anti-tumor immune cells, including T-cells, CAR-T- cells, and TILs, into tumor stroma to potentiate their anti-tumor activity.

adcure team

Henry Wyche

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Chief Executive Officer


Dmitry M. Shayakhmetov, PhD

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Co-Founder, Senior Vice-President, 

Chief Scientific Officer

Nelson C. Di Paolo, PhD

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Co-Founder, Vice-President, 

Director of Toxicology and Preclinical Development

Angel A. Rivera, PhD

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Chief Technology Officer

AdCure bio's partners

Intellectual Property Law

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Our intellectual property partner 

Corporate Law

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Our corporate law partner

Preclinical studies

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Research services agreement-based proof-of-concept and mechanism of action tests of AdCure Bio's oncolytic viruses are conducted in state-of-the-art laboratories of Emory University 

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AdCure Bio

AdCure Bio LLC | Century Springs West | 6000 Lake Forrest Drive, Suite 400 | Atlanta, GA 30328

Ph: (206)-334-6511 Email: info@adcurebio.com